As of August 27, the most downloaded/accessed paper in BMC Systems Biology is: D. van Dijk et al.: Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks, BMC Systems Biology, vol. 4, nr 1 pp. 96+17. 2010.
This paper received the ICCS best paper award 2010:
N. Zarrabi et al.: Modeling HIV-1 intracellular replication, Procedia Computer Science vol. 1, nr 1 pp. 555-564. Elsevier B.V., Amsterdam, May 2010.